CAM833 |
| Catalog No.GC65935 |
CAM833은 ChimRAD51 단백질에 대한 Kd가 366 nM인 BRCA2와 RAD51 사이의 상호작용에 대한 강력한 오르토스테릭 억제제입니다. 821d96072c2d58d8970e76f526b0f6b8CAM833은 또한 RAD51 올리고머화를 억제합니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2758364-02-0
Sample solution is provided at 25 µL, 10mM.
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CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization[1].
CAM833 (3.125-50 μM; 24 h) causes a concentration-dependent decrease in RAD51 foci and subsequent increase in DNA damage[1].
CAM833 (25 μM) inhibits RAD51 molecular clustering at DNA damage sites[1].
CAM833 (0-50 μM) inhibits DNA repair by homologous recombination[1].
CAM833 (20 μM; 0-72 h) potentiates radiation-induced cell-cycle arrest and increases apoptosis over time[1].
CAM833 (10 μM) causes a dose-dependent growth inhibition that is enhanced when combined with ionizing radiation[1].
CAM833 (20 μM; 96 h) potentiates the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells[1].
Cell Cycle Analysis[1]
| Cell Line: | HCT116 cells |
| Concentration: | 20 μM |
| Incubation Time: | 0-72 h |
| Result: | In the control the percentage of cells in the apoptotic subG1 fraction remains below 5% throughout, in the compound-treated cells this rises progressively to peak at 15% at 48 hours. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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