CAM833 |
| カタログ番号GC65935 |
CAM833 は、BRCA2 と RAD51 の間の相互作用の強力なオルソステリック阻害剤であり、ChimRAD51 タンパク質に対する Kd は 366 nM です。 CAM833 は RAD51 のオリゴマー化も阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2758364-02-0
Sample solution is provided at 25 µL, 10mM.
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CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization[1].
CAM833 (3.125-50 μM; 24 h) causes a concentration-dependent decrease in RAD51 foci and subsequent increase in DNA damage[1].
CAM833 (25 μM) inhibits RAD51 molecular clustering at DNA damage sites[1].
CAM833 (0-50 μM) inhibits DNA repair by homologous recombination[1].
CAM833 (20 μM; 0-72 h) potentiates radiation-induced cell-cycle arrest and increases apoptosis over time[1].
CAM833 (10 μM) causes a dose-dependent growth inhibition that is enhanced when combined with ionizing radiation[1].
CAM833 (20 μM; 96 h) potentiates the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells[1].
Cell Cycle Analysis[1]
| Cell Line: | HCT116 cells |
| Concentration: | 20 μM |
| Incubation Time: | 0-72 h |
| Result: | In the control the percentage of cells in the apoptotic subG1 fraction remains below 5% throughout, in the compound-treated cells this rises progressively to peak at 15% at 48 hours. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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