3'-Hydroxypterostilbene |
رقم الكتالوجGC35112 |
3'-Hydroxypterostilbene هو نظير Pterostilbene3'-Hydroxypterostilbene يثبط نمو خلايا COLO 205 و HCT-116 و HT-29 مع IC50s من 9.0 و 40.2 و 70.9 ميكرومتر على التوالي3'-Hydroxypterostilbene ينظم بشكل كبير مسارات إشارات PI3K / Akt و MAPKs ويمنع بشكل فعال نمو خلايا سرطان القولون البشرية عن طريق إحداث موت الخلايا المبرمج والالتهام الذاتييمكن استخدام 3'-Hydroxypterostilbene في البحث عن السرطان
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Cas No.: 475231-21-1
Sample solution is provided at 25 µL, 10mM.
3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1]. Apoptosis[1]Autophagy[1]
[1]. Cheng TC, et al. Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PLoS One. 2014 Nov 12;9(11):e111814.
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