- القط. رقم اسم المنتج بيانات
- GA20572 Ac-Gly-Lys-OMe Substrate for the determination of urokinase activity. It is also cleaved by thrombin, plasmin and trypsin as well as complement component C3/C5 convertases. Also known as GK-peptide, used in studies on protein glycation and formation of Maillard products.
- GA20534 Acetyl-Amyloid β-Protein (15-20) amide Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites.
- GA20283 (Pyr³)-Amyloid β-Protein (3-40) The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.
- GA20282 (Pyr¹¹)-Amyloid β-Protein (11-40) pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.
- GA20259 (Nle³⁵)-Amyloid β-Protein (1-40) The reactive thioether of Met³? is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
- GA20200 (Gly²²)-Amyloid β-Protein (1-42) The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42.
- GA20197 (Gly²¹)-Amyloid β-Protein (1-40) Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.
- GA20184 (Gln²²,Asn²³)-Amyloid β-Protein (1-40) Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.
- GA20050 (Cys⁰)-Amyloid β-Protein (1-40) Cys-Aβ1-40 can be easily and selectively modified, labeled, coupled to carriers e.g. by maleimide chemistry without affecting the sequences involved in fibril formation. The free mercapto moiety of the peptide adheres to gold surfaces.
- GA20042 (Asn⁷)-Amyloid β-Protein (1-40) The Tottori (D7N) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers.
- GA20041 (Asn⁶⁷⁰,Sta⁶⁷¹,Val⁶⁷²)-Amyloid β/A4 Protein Precursor₇₇₀ (662-675) Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC?? = 30 nM.
- GA20040 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676) This peptide substrate corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.
- GA20039 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675) SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.
- GA20029 (Arg¹³)-Amyloid β-Protein (1-40) H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.
- GC45565 Semax
- GC45490 Kisspeptin-54 (human) (trifluoroacetate salt)
- GC45489 K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
- GC45462 GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
- GC45434 Dipeptide diaminobutyroyl benzylamide (acetate)
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GC19550
LL-37, Human TFA
LL-37, Human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide
- GC45234 β-Endorphin (1-27) (human) (trifluoroacetate salt) β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors).
- GC45231 β-Defensin-4 (human) (trifluoroacetate salt) β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
- GC45230 β-Defensin-3 (human) (trifluoroacetate salt) β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
- GC45139 Vapreotide (trifluoroacetate salt) Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay).
- GC45130 Urodilatin Urodilatin is a renal natriuretic peptide first isolated from human urine.
- GC45096 Tyr-α-CGRP (human) (trifluoroacetate salt) Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide.
- GC45062 TNF-α Antagonist TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.
- GC44914 Somatostatin-14 (acetate) Somatostatin-14 is a natural cyclic peptide hormone derived from the preprohormone, somatostatin.
- GC44821 Reversin 121 Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance.
- GC44674 Pramlintide (acetate hydrate) Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29.
- GC44558 PAR3 (1-6) (human) PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence.
- GC44557 PAR2 (1-6) (mouse, rat) PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2.
- GC44533 PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.
- GC44531 PACAP (1-27) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt) Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC50 values of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.
- GC44526 Oxytocin (acetate) الأوكسيتوسين (الأسيتات) هو ببتيد متعدد الموجه ، تحت المهاد معروف بتسهيله للولادة ، والرضاعة ، والسلوكيات الاجتماعية الإيجابية.
- GC44518 Osteocalcin (1-49) (human) (trifluoroacetate salt) Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone.
- GC44484 Obestatin (rat) (trifluoroacetate salt) Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.
- GC44388 NF-κB Control NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.
- GC44374 Neuromedin B (trifluoroacetate salt) Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor).
- GC44257 Myelin Basic Protein (87-99) (human, bovine, rat) (trifluoroacetate salt) Myelin basic protein (MPB) (87-99) is an encephalitogenic peptide.
- GC44235 MMP Inhibitor I (trifluoroacetate salt) MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively).
- GC44078 LL-37 amide (trifluoroacetate salt) LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions.
- GC44034 Lariatin A Lariatin A is an antimycobacterial lasso peptide originally isolated from R.
- GC44032 Lanreotide (acetate) Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively).
- GC43888 Icatibant (acetate) Icatibant (acetate) (HOE-140 acetate) هو مضاد ببتيد قوي ومحدد لمستقبل bradykinin B2 مع IC50 و Ki 1.07 نانومتر و 0.798 نانومتر على التوالي.
- GC43846 Histone H3K27Me1 (23-34) (trifluoroacetate salt) Histone H3K27Me1 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences.
- GC43832 Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker.
- GC43831 Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker.
- GC43785 GRP (porcine) (trifluoroacetate salt) Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release.
- GC43784 GRP (human) (trifluoroacetate salt) Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release.
- GC43754 Ghrelin (rat) (trifluoroacetate salt) Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).
- GC43751 GHK GHK هو ثلاثي الببتيد يتكون من بقايا الجلايسين ، L- هيستيدين و L- ليسين المرتبطة بالتسلسل.
- GC43659 Feglymycin Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities.
- GC43645 Extracellular Death Factor Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing.
- GC43608 Endothelin-3 (human, rat) (trifluoroacetate salt) Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively).
- GC43398 Defensin HNP-3 (human) (trifluoroacetate salt) Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.
- GC43220 Cdk5 Substrate Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues.
- GC43215 CCK Octapeptide (non-sulfated), (trifluoroacetate salt) Cholecystokinin (CCK) octapeptide is a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC43214 CCK (26-31) (non-sulfated) CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC43213 CCK (26-30) (sulfated) CCK (26-30) is an N-terminal fragment of CCK, a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC43145 Casein Kinase 2 Substrate (trifluoroacetate salt) Casein kinase 2 substrate is a peptide substrate for casein kinase 2 (CK2).
- GC43129 CALP1 (trifluoroacetate salt) CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.
- GC43127 Calcitonin (salmon) (trifluoroacetate salt) Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.
- GC42973 Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt) Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF.
- GC42972 Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt) Brain-derived acidic fibroblast growth factor (brain-derived aFGF) (1-11) is a peptide fragment of brain-derived aFGF.
- GC42971 Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt) Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF).
- GC42936 Biotin Tripeptide-1 Biotin tripeptide-1 is an extracellular matrix (ECM) peptide that has been conjugated to biotin.
-
GC42809
Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt)
Angiotensin II (3-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II.
- GC42808 Angiotensin I (human, rat, mouse) (trifluoroacetate salt) Angiotensin I is an endogenous peptide that is converted to the vasoconstrictor angiotensin II by angiotensin-converting enzyme (ACE).
- GC42796 Amylin (human) (trifluoroacetate salt) Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.
- GC42701 Acetyl Tetrapeptide-3 Acetyl tetrapeptide-3 is a biomimetic peptide.
- GC33788 Adrenocorticotropic Hormone (ACTH) (18-39), human (CLIP (human)) الهرمون الموجه لقشر الكظر (ACTH) (18-39) ، الإنسان (CLIP (الإنسان)) هو ببتيد الفص المتوسط القشري ، والذي ينتج في الميلانوتروف للفص المتوسط من الغدة النخامية.
- GC33581 Nucleoprotein 118-126 (NP(118-126)) Nucleoprotein 118-126 (NP (118-126)) هو 9-aa peptide ، جزء من Nucleoprotein.
-
GC33369
Polymyxin B nonapeptide
البوليمكسين بي نوناببتايد، كببتايد دائرية موجبة الشحنة مستمدة من البوليمكسين ب، يمكن أن تزيد من نفاذية الغشاء الخارجي للجراثيم ذات الصفات السلبية المعروف باسم GNB تجاه المضادات الحيوية التى تتأثر بالطابع غير المائى.
- GC32772 Triptorelin ([DTrp6]-LH-RH) A synthetic GNRH peptide agonist
- GC32451 Examorelin (Hexarelin) A peptide agonist of GHS-R
- GC32332 PA (224-233), Influenza PA (224-233) ، الأنفلونزا عبارة عن 10-aa peptide ، جزء من بروتين polymerase 2 في فيروس الأنفلونزا A
- GC32316 MPG, HIV related MPG ، HIV المرتبط بـ 27-aa peptide ، مشتق من كل من تسلسل التوطين النووي لمستضد SV40 كبير T ومجال ببتيد الاندماج لـ HIV-1 gp41 وهو عامل توصيل فعال للتوصيل العام للأحماض النووية وأوليغنوكليوتيدات إلى المستنبتات الخلايا
- GC31530 ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human) ACTH 4-11 (هرمون قشر الكظر (4-11) ، الإنسان) ، وهو جزء من هرمون قشر الكظر ، يمتلك α ضعيفًا ؛ -الهرمون المنشط للخلايا الصباغية (α ؛ -MSH) فقط بجرعات عالية (100 و 1000 نانومتر).
- GC31179 β-Amyloid 31-35 &beta ؛ -Amyloid 31-35 هو أقصر سلسلة من Amyloid-peptide الأصلي الذي يحتفظ بالنشاط السام العصبي.
- GC30291 Calcitonin, eel (Thyrocalcitonin eel) كالسيتونين ، ثعبان البحر (ثيروكالسيتونين ثعبان البحر) هو هرمون الغدة الدرقية الببتيد الذي يساهم في تنظيم توازن الكالسيوم ، ويستخدم على نطاق واسع في البحث عن هشاشة العظام بعد سن اليأس.
- GC30108 Thymalfasin (Thymosin α1) Thymalfasin (Thymosin &alpha ؛ 1) هو عامل مناعي قادر على تعزيز الاستجابة المناعية Thl.
- GC18553 CCK (26-31) (sulfated) CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC18384 CCK (27-33) (non-sulfated) CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
-
GC18218
MMP-3 Inhibitor
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.
-
GC10284
Apelin-13
أبيلين-13 هو ببتيد معروف باسم ليغاند ال recepter المقترن ببروتين G APJ.
- GC10569 Nisin A Nisin A هو بكتيريوسين ينتج عن مجموعة من البكتيريا موجبة الجرام التي تنتمي إلى أنواع Lactococcus و Streptococcus.
- GC15319 Cyclosporin H Cyclosporin H هو مثبط انتقائي وقوي لـ FPR-1 (مستقبلات الببتيد الفورميل 1)
- GC10790 FSLLRY-NH2 FSLLRY-NH2 هو مثبط لمستقبلات البروتياز 2 (PAR2)
- GC12366 LPYFD-NH2 يمارس LPYFD-NH2 ، خماسي الببتيد ، بعض التأثير المثبط على تراكم Aβ (1-42)
- GC13077 RETF-4NA RETF-4NA ، ركيزة خاصة بالكيماز ، هي ركيزة حساسة وانتقائية للكيماز عندما تكون حرة أو مرتبطة بـ α2M
- GC17133 Hemopressin (human, mouse) الهيموبريسين هو نوناببتيد مشتق من سلسلة α1 من الهيموجلوبين ، وهو معزول في الأصل من متجانسات دماغ الفئران
- GC13806 Lys-γ3-MSH Lys-γ ؛ 3-MSH هو ببتيد الميلانوكورتين المشتق من الطرف C من جزء من pro-opiomelanocortin (POMC).
- GC15641 Parstatin (mouse) بارستاتين (فأر) ، وهو ببتيد ناهض لمستقبلات الثرومبين يخترق الخلايا ، وهو مثبط قوي لتكوين الأوعية.
- GC11514 Parstatin (human) بارستاتين (بشري) ، وهو ببتيد ناهض لمستقبل الثرومبين يخترق الخلايا ، وهو مثبط قوي لتكوين الأوعية.
- GC15356 Prion Protein 106-126 (human) بروتين البريون 106-126 (بشري) ، جزء من الببتيد من البريون ، ويمكنه إحداث موت الخلايا المبرمج للخلايا العصبية ، وهضم البروتين المضاد للبروتين K ، وتكوين الألياف ، والتوسط في تحويل بروتين البريون الخلوي الطبيعي (PrPc) إلى شكل إسوي ممرض (PrPSc)
- GC15522 Ac9-25 Ac9-25 ، وهو عبارة عن ببتيد طرفي N في الملحق الأول ، يعمل كمحفز لمستقبلات الببتيد (FPR) وينشط العدلات NADPH أوكسيديز من خلال FPR
- GC14222 [D-p-Cl-Phe6,Leu17]-VIP [D-p-Cl-Phe6، Leu17] -VIP هو مضاد تنافسي وانتقائي لمستقبلات الببتيد المعوي الفعال في الأوعية ، مع IC50 من 125.8 نانومتر
- GC15519 α-CGRP (human) &alpha ؛ -CGRP (الإنسان) عبارة عن ببتيد عصبي تنظيمي يتكون من 37 من الأحماض الأمينية.
- GC16094 Neuropeptide W-23 (human) Neuropeptide W-23 (بشري) (NPW-23) ، الشكل النشط من Neuropeptide W ، هو ناهض داخلي لـ NPBW1 (GPR7) و NPBW2 (GPR8)