Didesmethylrocaglamide |
| رقم الكتالوجGC39808 |
ديديسميثيلروكاجلاميد Didesmethylrocaglamide ، أحد مشتقات Rocaglamide ، هو مثبط قوي لعامل بدء حقيقيات النوى 4A (eIF4A)Didesmethylrocaglamide له نشاط مثبط قوي للنمو مع IC 50 من 5 نانومتريقوم Didesmethylrocaglamide بقمع العديد من مسارات الإشارات المعززة للنمو ويحث على موت الخلايا المبرمج في الخلايا السرطانيةنشاط انتيتومور
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Cas No.: 177262-30-5
Sample solution is provided at 25 µL, 10mM.
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Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity[1].
[1]. Long-Sheng Chang, et al. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Mol Cancer Ther. 2020 Mar;19(3):731-741.
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