Didesmethylrocaglamide |
Catalog No.GC39808 |
Rocaglamide의 유도체인 Didesmethylrocaglamide는 강력한 진핵생물 개시인자 4A(eIF4A) 억제제입니다. Didesmethylrocaglamide는 5 nM의 IC50으로 강력한 성장 억제 활성을 가지고 있습니다. Didesmethylrocaglamide는 여러 성장 촉진 신호 전달 경로를 억제하고 종양 세포에서 세포 사멸을 유도합니다. 항종양 활성.
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Cas No.: 177262-30-5
Sample solution is provided at 25 µL, 10mM.
Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity[1].
[1]. Long-Sheng Chang, et al. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Mol Cancer Ther. 2020 Mar;19(3):731-741.
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