DPBQ |
| رقم الكتالوجGC33384 |
ينشط DPBQ p53 ويؤدي إلى موت الخلايا المبرمج بطريقة محددة الصبغيات ، ولكنه لا يمنع توبويزوميراز أو يربط الحمض النوويينتج DPBQ التعبير والفسفرة لـ p53 وهذا التأثير خاص بالخلايا الرباعية الصبغية
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Cas No.: 7029-89-2
Sample solution is provided at 25 µL, 10mM.
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DPBQ is a p53 activator.
DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ[1].
[1]. Choudhary A, et al. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59.
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