Didesmethylrocaglamide |
| カタログ番号GC39808 |
ロカグラミドの誘導体であるジデスメチルロカグラミドは、強力な真核生物開始因子 4A (eIF4A) 阻害剤です。ジデスメチルロカグラミドは、IC50 が 5 nM の強力な増殖阻害活性を持っています。ジデスメチルロカグラミドは、複数の成長促進シグナル伝達経路を抑制し、腫瘍細胞のアポトーシスを誘導します。抗腫瘍活性。
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Cas No.: 177262-30-5
Sample solution is provided at 25 µL, 10mM.
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Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity[1].
[1]. Long-Sheng Chang, et al. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Mol Cancer Ther. 2020 Mar;19(3):731-741.
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