Didesmethylrocaglamide |
| Katalog-Nr.GC39808 |
Didesmethylrocaglamid, ein Derivat von Rocaglamid, ist ein potenter Hemmer des eukaryotischen Initiationsfaktors 4A (eIF4A). Didesmethylrocaglamid hat eine starke wachstumshemmende AktivitÄt mit einem IC50 von 5 nM. Didesmethylrocaglamid unterdrÜckt mehrere wachstumsfÖrdernde Signalwege und induziert Apoptose in Tumorzellen. Antitumor-AktivitÄt.
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Cas No.: 177262-30-5
Sample solution is provided at 25 µL, 10mM.
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Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity[1].
[1]. Long-Sheng Chang, et al. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Mol Cancer Ther. 2020 Mar;19(3):731-741.
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