DPBQ |
| Catalog No.GC33384 |
DPBQ는 p53을 활성화하고 배수체 특이적 방식으로 세포자멸사를 유발하지만 토포이소머라제를 억제하거나 DNA에 결합하지 않습니다. DPBQ는 p53의 발현과 인산화를 유도하며 이 효과는 4배체 세포에 특이적입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7029-89-2
Sample solution is provided at 25 µL, 10mM.
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DPBQ is a p53 activator.
DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ[1].
[1]. Choudhary A, et al. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59.
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