CYP17-IN-1 |
| رقم الكتالوجGC35788 |
CYP17-IN-1 (المركب 9c) هو مثبط فعال وفعال عن طريق الفم CYP17 ضد الفئران والبشر CYP17 مع IC50s من 15.8 و 20.1 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093317-51-0
Sample solution is provided at 25 µL, 10mM.
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CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1]. IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]
CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].
CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].
[1]. Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.
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