CYP17-IN-1 |
| Catalog No.GC35788 |
Le CYP17-IN-1 (composé 9c) est un inhibiteur du CYP17 puissant et actif par voie orale contre le CYP17 du rat et de l'homme avec des IC50 de 15,8 et 20,1 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093317-51-0
Sample solution is provided at 25 µL, 10mM.
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CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1]. IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]
CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].
CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].
[1]. Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.
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