Nitroaspirin |
| رقم الكتالوجGC36747 |
Nitroaspirin (NCX 4016) هو مانح لأكسيد النيتريك (NO) ومشتق نيترو من الأسبرين ، والذي يتحد مع Nitroaspirin لتثبيط انزيمات الأكسدة الحلقيةيحتوي Nitroaspirin (NCX 4016) على خصائص مضادة للتخثر ومضادة للصفائح الدموية ويعمل كمثبط مباشر وغير قابل للانعكاس لـ COX-1يتسبب Nitroaspirin (NCX 4016) في تحريض كبير لتوقف دورة الخلية وموت الخلايا المبرمج في خلايا سرطان المبيض البشرية المقاومة للسيسبلاتين عن طريق التنظيم الخافت لإشارات EGFR / PI3K / STAT3 وتعديل بروتينات عائلة Bcl-2
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 175033-36-0
Sample solution is provided at 25 µL, 10mM.
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Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4]. COX-1
[1]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8. [2]. Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G437-43. [3]. Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. [4]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8.
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