Nitroaspirin |
| Katalog-Nr.GC36747 |
Nitroaspirin (NCX 4016) ist ein Stickoxid (NO)-Donor und ein Nitro-Derivat von Aspirin, das sich mit Nitroaspirin verbindet, um die Cyclooxygenase zu hemmen. Nitroaspirin (NCX 4016) hat antithrombotische und gerinnungshemmende Eigenschaften und wirkt als direkter und irreversibler Inhibitor von COX-1. Nitroaspirin (NCX 4016) verursacht eine signifikante Induktion von Zellzyklusstillstand und Apoptose in Cisplatin-resistenten menschlichen Eierstockkrebszellen durch Herunterregulierung der EGFR/PI3K/STAT3-SignalÜbertragung und Modulation von Proteinen der Bcl-2-Familie.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 175033-36-0
Sample solution is provided at 25 µL, 10mM.
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Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4]. COX-1
[1]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8. [2]. Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G437-43. [3]. Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. [4]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8.
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