PHT-7.3 |
| رقم الكتالوجGC36901 |
PHT-7.3 هو مثبط انتقائي لمُحسِّن الموصل لمثبط كيناز لمجال تماثل Ras 1 (Cnk1) pleckstrin (PH) (Kd = 4.7 ميكرومتر)يثبط PHT-7.3 الخلايا السرطانية KRas ، ولكن ليس من النوع البري KRas ونمو الورم والإشاراتPHT-7.3 له نشاط مضاد للأورام
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1614225-93-2
Sample solution is provided at 25 µL, 10mM.
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PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain, which inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling[1]. Cnk1 PH-domain[1]
[1]. Indarte M ,et al. An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors. Cancer Res. 2019 Jun 15;79(12):3100-3111.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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