PHT-7.3 |
Catalog No.GC36901 |
PHT-7.3 es un inhibidor selectivo del potenciador del conector del supresor de quinasa del dominio de homologÍa (PH) pleckstrina Ras 1 (Cnk1) (Kd = 4,7 μM). PHT-7.3 inhibe mut-KRas, pero no el crecimiento y la seÑalizaciÓn de células cancerosas y tumores de KRas de tipo salvaje. PHT-7.3 tiene actividad antitumoral.
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Cas No.: 1614225-93-2
Sample solution is provided at 25 µL, 10mM.
PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain, which inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling[1]. Cnk1 PH-domain[1]
[1]. Indarte M ,et al. An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors. Cancer Res. 2019 Jun 15;79(12):3100-3111.
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