Procyanidin B3 (Synonyms: (+)-Catechin-(4α→8)-(+)-catechin, Proanthocyanidin B3, Procyanidol B3) |
| رقم الكتالوجGC36975 |
Procyanidin B3 هو منتج طبيعي ، يعمل كمثبط معين لـ HAT ، ويرتبط بالموقع الآخر لـ p300 بدلاً من الموقع النشط ، ويمنع بشكل انتقائي أستلة مستقبل الأندروجين بوساطة p300ليس لـ Procyanidin B3 أي تأثير على HDAC أو HMT (هيستون ميثيل ترانسفيراز)
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Cas No.: 23567-23-9
Sample solution is provided at 25 µL, 10mM.
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Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1]. p300[1]
[1]. Choi KC, et al. Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Biochem J. 2011 Jan 1;433(1):235-44.
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