WRG-28 |
Catalog No.GC38206 |
WRG-28 es un inhibidor alostérico DDR2 selectivo de acciÓn extracelular, con una IC50 de 230 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1913291-02-7
Sample solution is provided at 25 µL, 10mM.
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].
[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.
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