IWP-O1 |
رقم الكتالوجGC34628 |
IWP-O1 هو مثبط قوي للغاية لـ Porcupine (Porcn) ، مع EC50 من 80 pM في خلايا L-Wnt-STFيمنع IWP-O1 إفراز بروتينات Wntيمنع IWP-O1 فسفرة Dvl2 / 3 و LRP6 في خلايا هيلا
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Cas No.: 2074607-48-8
Sample solution is provided at 25 µL, 10mM.
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1]. EC50: 80 pM (Porcn)[1].
[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.
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