IWP-O1 |
| Catalog No.GC34628 |
IWP-O1 es un inhibidor de puercoespÍn (Porcn) muy potente, con una EC50 de 80 pM en células L-Wnt-STF. IWP-O1 previene la secreciÓn de proteÍnas Wnt. IWP-O1 suprime la fosforilaciÓn de Dvl2/3 y LRP6 en células HeLa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2074607-48-8
Sample solution is provided at 25 µL, 10mM.
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IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1]. EC50: 80 pM (Porcn)[1].
[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.
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