IWP-O1 |
| カタログ番号GC34628 |
IWP-O1 は非常に強力なヤマアラシ (Porcn) 阻害剤であり、L-Wnt-STF 細胞での EC50 は 80 pM です。 IWP-O1 は、Wnt タンパク質の分泌を防ぎます。 IWP-O1 は、HeLa 細胞における Dvl2/3 および LRP6 のリン酸化を抑制します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2074607-48-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1]. EC50: 80 pM (Porcn)[1].
[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *