LSD1-IN-7 benzenesulfonate (Synonyms: CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate) |
| رقم الكتالوجGC39287 |
CC-90011 benzenesulfonate هو مثبط فعال وانتقائي وقابل للانعكاس ونشط عن طريق الفم لمزيل ميثيلاز -1 ليسين محدد (LSD1) مع IC 50 من 0.25 نانومتر. CC-90011 benzenesulfonate أقل تثبيطًا إنزيميًا ضد LSD2 و MOA-A و MAO-B. CC-90011 benzenesulfonate يحث على تمايز خلايا سرطان الدم النخاعي الحاد (AML) وخلايا سرطان الرئة ذات الخلايا الصغيرة (SCLC) وله نشاط قوي مضاد للسرطان.
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Cas No.: 2097523-60-7
Sample solution is provided at 25 µL, 10mM.
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LSD1-IN-7 benzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity extracted from patent WO2017079670A1, compound 4-[2-(4-amino-piperidin-1-yl)-5-(3-fluoro-4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-4-yl]-2-fluorobenzonitrile[1].
[1]. Young K. Chen, et al. Compositions comprising an inhibitor of lysine specific demethylase-1. WO2017079670A1.
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