LSD1-IN-7 benzenesulfonate (Synonyms: CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate) |
| Catalog No.GC39287 |
Le benzènesulfonate CC-90011 est un inhibiteur puissant, sélectif, réversible et oralement actif de la déméthylase-1 spécifique de la lysine (LSD1) avec une IC50 de 0,25 nM. Le benzènesulfonate CC-90011 est moins inhibiteur enzymatique contre LSD2, MOA-A et MAO-B. Le benzènesulfonate CC-90011 induit la différenciation des cellules de la leucémie myéloÏde aiguë (LMA) et du cancer du poumon À petites cellules (SCLC) et possède une puissante activité anticancéreuse.
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Cas No.: 2097523-60-7
Sample solution is provided at 25 µL, 10mM.
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LSD1-IN-7 benzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity extracted from patent WO2017079670A1, compound 4-[2-(4-amino-piperidin-1-yl)-5-(3-fluoro-4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-4-yl]-2-fluorobenzonitrile[1].
[1]. Young K. Chen, et al. Compositions comprising an inhibitor of lysine specific demethylase-1. WO2017079670A1.
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