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LTURM34

رقم الكتالوجGC19227

LTURM34 هو مثبط محدد لـ DNA-PK (IC50 = 34 نانومتر)يعرض LTURM34 انتقائية 170 ضعفًا لـ DNA-PK على PI3Kيُظهر LTURM34 نشاطًا قويًا مضادًا للتكاثر في مجموعة واسعة من خطوط الخلايا السرطانية

Products are for research use only. Not for human use. We do not sell to patients.

LTURM34 التركيب الكيميائي

Cas No.: 1879887-96-3

الحجم السعر المخزون الكميّة
5mg
74٫00
متوفر
10mg
121٫00
متوفر
50mg
482٫00
متوفر
100mg
803٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com

مراجعات العميل

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Protocol Chemical Properties Product Documents Related Products

LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.

LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 uM for PI3K β and δ, respectively. LTURM34 shows potent and broad ranging antiproliferative activity. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line[1].

References:
[1]. Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.

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