LTURM34 |
| Catalog No.GC19227 |
LTURM34 est un inhibiteur spécifique de la DNA-PK (IC50=34 nM). LTURM34 présente une sélectivité de 170 fois pour l'ADN-PK par rapport À PI3K. LTURM34 présente une puissante activité antiproliférative dans un large éventail de lignées cellulaires tumorales.
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Cas No.: 1879887-96-3
Sample solution is provided at 25 µL, 10mM.
LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.
LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 uM for PI3K β and δ, respectively. LTURM34 shows potent and broad ranging antiproliferative activity. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line[1].
References:
[1]. Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.
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