LTURM34 |
| Catalog No.GC19227 |
LTURM34는 특정 DNA-PK 억제제(IC50=34nM)입니다. LTURM34는 PI3K에 비해 DNA-PK에 대해 170배 선택성을 나타냅니다. LTURM34는 광범위한 종양 세포주에서 강력한 항증식 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1879887-96-3
Sample solution is provided at 25 µL, 10mM.
LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.
LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 uM for PI3K β and δ, respectively. LTURM34 shows potent and broad ranging antiproliferative activity. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line[1].
References:
[1]. Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *