Nemadipine A |
رقم الكتالوجGC44361 |
Nemadipine A هو مثبط محدد لقناة EGL-19 L-type Ca2+. Nemadipine A ، مثبط قناة الكالسيوم من النوع L المنفذ للخلايا ، يحسس الخلايا السرطانية المقاومة لـ TRAIL لهذا الترابط.
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Cas No.: 54280-71-6
Sample solution is provided at 25 µL, 10mM.
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
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