Nemadipine A |
| Catalog No.GC44361 |
La nemadipina A es un inhibidor específico del canal Ca2+ de tipo L de EGL-19. La nemadipina A, un inhibidor de los canales de calcio de tipo L permeable a las células, sensibiliza a las células cancerosas resistentes a TRAIL a este ligando.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54280-71-6
Sample solution is provided at 25 µL, 10mM.
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Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
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