Nemadipine A |
| Katalog-Nr.GC44361 |
Nemadipin A ist ein spezifischer Inhibitor des EGL-19-L-Typ-Ca2+-Kanals. Nemadipin A, ein zellgängiger Calciumkanal-Inhibitor vom L-Typ, sensibilisiert TRAIL-resistente Krebszellen für diesen Liganden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54280-71-6
Sample solution is provided at 25 µL, 10mM.
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Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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