NSC 636819 |
| Catalog No.GC50136 |
NSC 636819는 KDM4A/KDM4B의 경쟁적이고 선택적 억제제입니다. KDM4A/KDM4B는 전립선암의 잠재적인 진행 요인입니다. NSC 636819는 암 질환, 특히 전립선암 연구에 대한 잠재력을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1618672-71-1
Sample solution is provided at 25 µL, 10mM.
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KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID:24971742
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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