NSC 636819 |
| Catalog No.GC50136 |
NSC 636819 est un inhibiteur compétitif et sélectif de KDM4A/KDM4B. KDM4A/KDM4B sont des facteurs potentiels de progression du cancer de la prostate. NSC 636819 a le potentiel pour la recherche sur les maladies cancéreuses, en particulier le cancer de la prostate.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1618672-71-1
Sample solution is provided at 25 µL, 10mM.
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KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID:24971742
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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