Membrane Transporter/Ion Channel
Research Areas
- AMPAR(55)
- Aquaporins(3)
- Piezo Channels(6)
- ATPase(79)
- Calcium Channel(357)
- Cannabinoid Transporters(6)
- CFTR(51)
- Chloride Channels(12)
- GABA Receptor(203)
- Glucose Transporters(17)
- Glutamate (EAAT) Transporters(18)
- Glycine Receptors(2)
- GlyT(20)
- GTPase(31)
- ICB(1)
- MCT2(2)
- Monoamine transporter(17)
- Monocarboxylate Transporters(14)
- Multidrug Transporters(4)
- Na+/Ca2+ Exchanger(16)
- NKCC(9)
- NMDA Receptor(77)
- Nucleoside Transporters(6)
- Pannexin-1(2)
- P2X purinergic receptor(71)
- P-gp(10)
- Proton Pump(59)
- Potassium Channel(335)
- Sodium Channel(228)
- TRP Channel(190)
- TRPV1(10)
- URAT1(14)
- Other Channel Modulators(10)
- MCT(3)
- Kainate Receptors(11)
- Ionophore(3)
- sodium-hydrogen exchanger(3)
- Chloride Channel(33)
- CRAC Channel(14)
- EAAT2(6)
- HCN Channel(10)
- Na+/HCO3- Cotransporter(1)
- Na+/K+ ATPase(31)
- P-glycoprotein(60)
- iGluR(183)
- nAChR(125)
- VDAC(3)
- GlyR(1)
- Ferroportin(4)
- Urea Transporter(1)
- Na+/H+ Exchanger (NHE)(3)
- NTPDase(4)
- EAAT(7)
- ASCT(6)
- Apical Sodium-Dependent Bile Acid Transporter(1)
- Sec61(2)
- ATP-binding cassette (ABC) transporters(5)
- SLC39 (Zinc Transporter)(2)
- Sodium Phosphate Cotransporter(1)
Products Related to Membrane Transporter/Ion Channel(2450)
- GC84046Sazetidine A dihydrochlorideCAS: 2455450-63-0Purity: >98.50%
Sazetidine A dihydrochloride is a potent ligand for the α4β2 nAChR, with high binding affinity and selectivity for this subtype.
- GC84061SelurampanelCAS: 912574-69-7Purity: >99.00%
Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC 50 of 190 nM.
- GC84081SimpiniclineCAS: 753015-44-0Purity: >98.00%
Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor ( nAChR ) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC 50 of 0.04 µM [1] .
- GC84085SivopixantCAS: 2414285-40-6Purity: >99.50%
Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM).
- GC84091SLC26A4-IN-1CAS: 5010-56-0Purity: >99.00%
SLC26A4-IN-1 (compound 1a) is a pendrin/SLC26A4 inhibitor.
- GC84092SLC6A8 corrector 1Purity: >99.50%
SLC6A8 corrector 1 is an orally active and brain-penetrant mutant SLC6A8 variant corrector.
- GA10750L-Glutamic acidCAS: 56-86-0Purity: >99.00%
L-Glutamic acid is the main excitatory neurotransmitter in the mammalian central nervous system (CNS). L-Glutamic acid has two major types of receptors: ionotropic (NMDA-, AMPA-, and kainate-selective iGluRs) and metabotropic glutamate receptors. L-Glutamic acid induces excitotoxicity by activating the postsynaptic N-methyl-D-aspartate receptors, leading to neurodegenerative diseases.
- GA20775Anxiety PeptideCAS: 95237-86-8Purity: >98.00%
Anxiety Peptide, also known as Octadecaneuropeptide (ODN), is produced by trypsin digestion of diazepam binding inhibitor (DBI).
- GA22579H-Ile-Trp-OHCAS: 13589-06-5Purity: >98.00%
H-Ile-Trp-OH (H-Ile-Trp-OH) ist ein oral aktiver α7 nAChR negativer VerÄnderungsmodulator (NAM) ohne offensichtliche Nebenwirkungen.
- GA24016ω-Conotoxin MVIIACAS: 107452-89-1Purity: >98.00%
ω-Conotoxin MVIIA (SNX-111), ein Peptid, ist ein wirksamer und selektiver Blocker des N-Typ-Calciumkanal-Antagonisten.
- GC10101SR 95531 hydrobromideCAS: 104104-50-9Purity: >97.00%
SR 95531 hydrobromide (Gabazine) ist ein selektiver Antagonist an den GABA-Bindungsstäten der GABAA-Rezeptoren.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC84046 | Sazetidine A dihydrochloride | 2455450-63-0 | >98.50% | |
Sazetidine A dihydrochloride is a potent ligand for the α4β2 nAChR, with high binding affinity and selectivity for this subtype. | ||||
| GC84059 | Selank | 129954-34-3 | >99.50% | |
Selank (Selanc; TP-7) is a GABAA receptor modulator with anxiolytic activity. | ||||
| GC84061 | Selurampanel | 912574-69-7 | >99.00% | |
Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC 50 of 190 nM. | ||||
| GC84081 | Simpinicline | 753015-44-0 | >98.00% | |
Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor ( nAChR ) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC 50 of 0.04 µM [1] . | ||||
| GC84085 | Sivopixant | 2414285-40-6 | >99.50% | |
Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). | ||||
| GC84091 | SLC26A4-IN-1 | 5010-56-0 | >99.00% | |
SLC26A4-IN-1 (compound 1a) is a pendrin/SLC26A4 inhibitor. | ||||
| GC84092 | SLC6A8 corrector 1 | - | >99.50% | |
SLC6A8 corrector 1 is an orally active and brain-penetrant mutant SLC6A8 variant corrector. | ||||
| GC84100 | SN05 | 2768663-51-8 | >98.00% | |
SN05 is a potent amino acid transport (AAT) inhibitor with K i values of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for hASCT1, rASCT2, hASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. | ||||
| GC84102 | SN40 | 2768663-14-3 | >99.00% | |
SN40 is a potent amino acid transport (AAT) inhibitor with K i s of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. | ||||
| GA10299 | H-Phe-OH | 63-91-2 | >99.00% | |
| GA10750 | L-Glutamic acid | 56-86-0 | >99.00% | |
L-Glutamic acid is the main excitatory neurotransmitter in the mammalian central nervous system (CNS). L-Glutamic acid has two major types of receptors: ionotropic (NMDA-, AMPA-, and kainate-selective iGluRs) and metabotropic glutamate receptors. L-Glutamic acid induces excitotoxicity by activating the postsynaptic N-methyl-D-aspartate receptors, leading to neurodegenerative diseases. | ||||
| GA10922 | H-Gly-OH | 56-40-6 | >99.50% | |
| GA11306 | H-D-Ser-OH | 312-84-5 | >99.00% | |
An NMDA co-agonist | ||||
| GA11338 | H-D-Asp-OH | 1783-96-6 | >99.00% | |
An amino acid and a precursor in NMDA biosynthesis | ||||
| GA20418 | 4-Hydroxy-hippuric acid | 2482-25-9 | >98.00% | |
Polyphenol metabolite. | ||||
| GA20775 | Anxiety Peptide | 95237-86-8 | >98.00% | |
Anxiety Peptide, also known as Octadecaneuropeptide (ODN), is produced by trypsin digestion of diazepam binding inhibitor (DBI). | ||||
| GA22579 | H-Ile-Trp-OH | 13589-06-5 | >98.00% | |
H-Ile-Trp-OH (H-Ile-Trp-OH) ist ein oral aktiver α7 nAChR negativer VerÄnderungsmodulator (NAM) ohne offensichtliche Nebenwirkungen. | ||||
| GA24016 | ω-Conotoxin MVIIA | 107452-89-1 | >98.00% | |
ω-Conotoxin MVIIA (SNX-111), ein Peptid, ist ein wirksamer und selektiver Blocker des N-Typ-Calciumkanal-Antagonisten. | ||||
| GC10038 | Vernakalant Hydrochloride | 748810-28-8 | >99.00% | |
| GC10043 | D-CPP-ene | 117414-74-1 | >98.00% | |
NMDA antagonist | ||||
| GC10065 | (-)-Bicuculline methiodide | 40709-69-1 | >98.00% | |
GABAA receptor antagonist | ||||
| GC10085 | DQP 1105 | 380560-89-4 | >98.00% | |
DQP 1105 ist ein potenter nichtkompetitiver NMDA-Rezeptorantagonist. | ||||
| GC10094 | BL 1249 | 18200-13-0 | >98.00% | |
BL 1249 ist ein nichtsteroidales Antirheumatikum (NSAID) und ein Kaliumkanalaktivator. | ||||
| GC10101 | SR 95531 hydrobromide | 104104-50-9 | >97.00% | |
SR 95531 hydrobromide (Gabazine) ist ein selektiver Antagonist an den GABA-Bindungsstäten der GABAA-Rezeptoren. | ||||