4-methoxy Estrone (Synonyms: 4-MeOE1, 4-methoxy E1) |
| Catalog No.GC49562 |
An active metabolite of estrone
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Cas No.: 58562-33-7
Sample solution is provided at 25 µL, 10mM.
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4-methoxy Estrone is an active metabolite of the endogenous estrogen estrone .1 It is formed from estrone by catechol-O-methyltransferase (COMT). 4-methoxy Estrone (10 and 100 nM) increases the proliferation of human umbilical vein endothelial cells (HUVECs).2
1.Dawling, S., Roodi, N., Mernaugh, R.L., et al.Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: Comparison of wild-type and variant COMT isoformsCancer Res.61(18)6716-6722(2001) 2.Lippert, C., Seeger, H., Mueck, A.O., et al.The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cellsLife Sci.67(13)1653-1658(2000)
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