6-Phosphogluconic acid trisodium |
| Catalog No.GC65015 |
L'acide 6-phosphogluconique trisodique est un inhibiteur puissant et compétitif de la phosphoglucose isomérase (PGI) avec un Kis de 48 μM pour le glucose 6-phosphate et de 42 μM pour le fructose 6-phosphate.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53411-70-4
Sample solution is provided at 25 µL, 10mM.
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6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].
6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.
[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.
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