6-Phosphogluconic acid trisodium |
| Katalog-Nr.GC65015 |
6-PhosphogluconsÄuretrinatrium ist ein potenter und kompetitiver Phosphoglucoseisomerase (PGI)-Hemmer mit einem Kis von 48 μM fÜr Glucose-6-phosphat und 42 μM fÜr Fructose-6-phosphat.
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Cas No.: 53411-70-4
Sample solution is provided at 25 µL, 10mM.
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6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].
6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.
[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.
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