Adenylosuccinic Acid (Synonyms: Aspartyl Adenylate) |
| Catalog No.GC46083 |
L'acide adénylosuccinique est un nucléotide purique et un intermédiaire dans le cycle des nucléotides puriques.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19046-78-7
Sample solution is provided at 25 µL, 10mM.
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Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.[1] It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 µM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.[2] Adenylosuccinic acid (10 µM) increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells.[3] It induces contractions in isolated guinea pig uterus strips when used at a concentration of 100 µM.[4]
Reference:
[1]. Waarde, A. Operation of the purine nucleotide cycle in animal tissues. Biol. Rev. Camb. Philos. Soc. 63(2), 259-298 (1988).
[2]. Halonen, J., and Nedergaard, J. Adenosine 5'-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channel. J. Membr. Biol. 188(1), 183-197 (2002).
[3]. Gooding, J.R., Jensen, M.W., Dai, X., et al. Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism. Cell Rep. 13(1), 157-167 (2015).
[4]. Nishida, Y., and Miyamoto, T. Contractile effect of succinylpurines on guinea pig uterus. Gen. Pharmacol. 19(2), 277-279 (1988).
| Cas No. | 19046-78-7 | SDF | |
| Synonymes | Aspartyl Adenylate | ||
| Chemical Name | N-[9-(5-O-phosphono-β-D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid | ||
| Canonical SMILES | OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@@]1([H])N2C=NC3=C(N[C@@H](CC(O)=O)C(O)=O)N=CN=C32)(O)=O | ||
| Formula | C14H14N5O11P • 4NH4 | M.Wt | 531.4 |
| Solubility | PBS (pH 7.2);10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.8818 mL | 9.4091 mL | 18.8182 mL |
| 5 mM | 376.4 μL | 1.8818 mL | 3.7636 mL |
| 10 mM | 188.2 μL | 940.9 μL | 1.8818 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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