AMG 837 hemicalcium salt |
| Catalog No.GC50333 |
Le sel d'hémicalcium AMG 837 est un agoniste puissant, biodisponible par voie orale et partiel de GPR40/FFA1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1291087-14-3
Sample solution is provided at 25 µL, 10mM.
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Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC50 values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid . Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.
Houze et al (2012) AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg.Med.Chem.Lett. 22 1267 PMID:22217876 |Lin et al (2012) Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol.Pharmacol. 82 843 PMID:22859723 |Lin et al (2011) AMG 837: a novel GPR40/FFA1 agonist that enhances Ins secretion and lowers glucose levels in rodents. PLoS One 6 e27270 PMID:22087278
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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