Amino-PEG5-C2-acid |
| Catalog No.GC65193 |
L'amino-PEG5-C2-acide est un lieur PROTAC À base de PEG qui peut être utilisé dans la synthèse des PROTAC. L'amino-PEG5-C2-acide est un lieur ADC non clivable utilisé dans la synthèse de conjugués anticorps-médicament (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1191078-74-6
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG5-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Gregory L. Verdine, et al. Stabilized polypeptide insulin receptor modulators. WO2014201370A1.
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