Ammonium chloride |
| Catalog No.GC63316 |
Le chlorure d'ammonium, en tant que composé hétéropolaire avec régulation de la valeur du pH, peut provoquer une alcalinisation intracellulaire et une acidose métabolique, affectant ainsi l'activité enzymatique et influenÇant le processus du système biologique. Le chlorure d'ammonium est un inhibiteur de l'autophagie.
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Cas No.: 12125-02-9
Sample solution is provided at 25 µL, 10mM.
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Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor[1][2].
Ammonium chloride (NH4Cl), a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells[2].
Ammonium chloride (0.28 M in drinking water) promotes the survival of myocardial cells in vivo by decreasing contractile dysfunction, cardiac hypertrophy, inflammation, apoptosis and autophagy[1].
[1]. Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100. [2]. Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988.
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