Azido-PEG3-maleimide |
| Catalog No.GC64056 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1858264-36-4
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
[1]. Deshmukh AA, et al. Detection of Protease Activity by Fluorescent Peptide Zymography. J Vis Exp. 2019 Jan 20;(143).
[2]. Allo B, et al. Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjug Chem. 2018 Jun 20;29(6):2028-2038.
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