Azido-PEG4-C2-acid |
| Catalog No.GC63798 |
Azido-PEG4-C2-acide un lieur PROTAC À base de PEG peut être utilisé dans la synthèse de vRucaparib-TP4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1257063-35-6
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.
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