BAY-1895344 (Synonyms: Elimusertib) |
| Catalog No.GC33420 |
BAY-1895344 (BAY-1895344) est un inhibiteur ATR puissant, actif par voie orale et sélectif avec une IC50 de 7 nM. BAY-1895344 a une activité antitumorale. BAY-1895344 peut être utilisé pour la recherche de tumeurs solides et de lymphomes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1876467-74-1
Sample solution is provided at 25 µL, 10mM.
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BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].
BAY-1895344 potently inhibits the proliferation of a broad spectrum of human tumor cell lines with a median IC50 of 78 nM[1].BAY-1895344 potently suppresses hydroxyurea-induced H2AX phosphorylation (IC50, 36 nM)[1].
BAY-1895344 shows potent anti-tumor efficacy in monotherapy in a variety of xenograft models of ovarian and colorectal cancer, and causes complete tumor remission in mantle cell lymphoma models[2].
[1]. Ulrich T. Luecking, et al. Abstract 983: Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement. [2]. Antje Margret Wengner, et al. Abstract 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement
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