BTYNB IMP1 Inhibitor |
| Catalog No.GC42986 |
L'inhibiteur BTYNB IMP1 est un inhibiteur puissant et sélectif de la liaison d'IMP1 À l'ARNm de c-Myc (IC50=5 μM). L'inhibiteur BTYNB IMP1 présente une sélectivité et une efficacité contre les lignées cellulaires cancéreuses positives À IMP1. L'inhibiteur BTYNB IMP1 peut être utilisé pour la recherche sur le cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 304456-62-0
Sample solution is provided at 25 µL, 10mM.
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BTYNB IMP1 inhibitor is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). [1] It downregulates c-Myc and β-TrCP1 mRNA and reduces IMP1 protein levels in SK-MEL-2 and IGROV-1 cells. BTYNB IMP1 inhibits proliferation of IMP1-positive ES-2, IGROV-1, and SK-MEL-2 cells (IC50s = 2.3, 3.6, and 4.5 μM, respectively) but not IMP1-negative BG-1 and T47D-KBluc cells (IC50s = >50 μM for both). It also inhibits anchorage-independent growth of SK-MEL-2 cells when used at a concentration of 10 μM.
Reference:
[1]. Mahapatra, L., Andruska, N., Mao, C., et al. A novel IMP1 inhibitor, BTYNB, targets c-Myc and inhibits melanoma and ovarian cancer cell proliferation. Transl. Oncol. 10(5), 818-827 (2017).
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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