Caroverine hydrochloride (Synonyms: Tinnex hydrochloride) |
| Catalog No.GC61963 |
Le chlorhydrate de caroverine (Tinnex) est un antagoniste puissant, compétitif et réversible des récepteurs NMDA et AMPA du glutamate.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 55750-05-5
Sample solution is provided at 25 µL, 10mM.
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Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3].
Caroverine (1 µM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 µM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta[3].
Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat[4].
References:
[1]. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56.
[2]. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30.
[3]. Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8.
[4]. Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7.
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