Beauveriolide III |
| Catalog No.GC46912 |
Le beauvériolide III est un inhibiteur de la formation de gouttelettes lipidiques dans les macrophages de souris.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 221111-70-2
Sample solution is provided at 25 µL, 10mM.
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Beauveriolide III is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.1 It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC50 = 0.41 µM), in primary mouse peritoneal macrophages.1,2 Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 5.5 µM).2 Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic atherosclerotic lesions in Ldlr-/- and ApoE-/- mouse models of atherosclerosis.
1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979J. Antibiot. (Tokyo)52(1)1-6(1999) 2.Namatame, I., Tomoda, H., Ishibashi, S., et al.Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophagesProc. Nat. Acad. Sci. USA101(3)737-742(2004)
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