CAY10753 |
| Catalog No.GC47056 |
A TNKS2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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CAY10753 is an inhibitor of tankyrase 2 (TNKS2; IC50 = 0.3 nM).1 It is selective for TNKS2 over TNKS1 (IC50 = 6.1 nM), as well as poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 89.6 and 37.8 nM, respectively). CAY10753 inhibits proliferation of DLD-1 colorectal cancer cells when used at a concentration of 1 µM.
1.Tomassi, S., Pfahler, J., Mautone, N., et al.From PARP1 to TNKS2 inhibition: A structure-based approachMed. Chem. Lett.(2020)
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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