JKE-1674 |
| Catalog No.GC47477 |
JKE-1674 est un inhibiteur de la glutathion peroxydase 4 (GPX4) actif par voie orale et un métabolite actif de l'inhibiteur de GPX4 ML-210. JKE-1674, un analogue du ML-210 dans lequel le cycle nitrosoxazole est remplacé par un α-nitrocétoxime. JKE-1674 peut se convertir en oxyde de nitrile JKE-1777. JKE-1674 tue les cellules LOX-IMVI d'une manière qui est équipotente À ML-210 et est complètement sauvé par les inhibiteurs de la ferroptose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2421119-60-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 .1 JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 = 0.03 µM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *