Diflucortolone 21-valerate |
| Catalog No.GC48491 |
Le 21-valérate de diflucortolone est un puissant corticostéroÏde utilisé par voie topique pour la recherche de diverses maladies de la peau.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 59198-70-8
Sample solution is provided at 25 µL, 10mM.
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Diflucortolone 21-valerate is a glucocorticoid.1 It has anti-inflammatory effects in a rat model of croton oil-induced ear edema when applied topically (ED50 = 9.7 µg/ml).2 Diflucortolone 21-valerate (0.1%) also induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration and increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization.3,1 Formulations containing diflucortolone 21-valerate have been used in the treatment of inflammatory or allergic skin conditions.
1.Igawa, K., Katayama, I., Minatohara, K., et al.Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivityAllergol. Int.46(1)33-41(1997) 2.Yamada, K., Hattori, S., Hakoda, T., et al.A fundamental study on a bioassay for the antiphlogistic effect of topically applied antiinflammatory agentsNihon Yakurigaku Zasshi75(8)789-798(1979) 3.Kimura, T., and Doi, K.Dorsal skin reactions of hairless dogs to topical treatment with corticosteroidsToxicol. Pathol.27(5)528-535(1999)
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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