Accueil>>Nucleotides/Nucleosides>>5'-Thymidylic Acid (sodium salt)

5'-Thymidylic Acid (sodium salt) (Synonyms: Deoxythymidine-5’-monophosphate, Thymidine monophosphate, Thymidine-5’-monophosphate, dTMP)

Catalog No.GC48662

5'-L'acide thymidylique (sel de sodium) est un métabolite endogène.

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5'-Thymidylic Acid (sodium salt) Chemical Structure

Cas No.: 33430-62-5

Taille Prix Stock Qté
100mg
35,00 $US
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250mg
66,00 $US
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1g
226,00 $US
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents

5'-Thymidylic acid (dTMP) is a deoxyribonucleotide.1 It is formed via methylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis.2 Oral administration of dTMP in combination with dCMP increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.3

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002) 2.Lee, L.S., and Cheng, Y.Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemiaJ. Biol. Chem.252(16)5686-5691(1977) 3.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)

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