Tilmicosin-d3 (Synonyms: LY-177370-d3; EL-870-d3) |
| Catalog No.GC49076 |
An internal standard for the quantification of tilmicosin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Tilmicosin-d3 is intended for use as an internal standard for the quantification of tilmicosin by GC- or LC-MS. Tilmicosin is a macrolide antibiotic.1 It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM), and inhibits bacterial protein synthesis (IC50 = 0.36 µM). Tilmicosin (75 mg/kg) increases serum creatine kinase (CK), the MB isoform of CK (CK-MB), and malondialdehyde (MDA) levels in mice, indicating cardiotoxicity.2 Formulations containing tilmicosin have been used in the treatment of respiratory diseases in sheep and cattle.
1.Andersen, N.M., Poehlsgaard, J., Warrass, R., et al.Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolidesAntimicrob. Agents Chemother.56(11)6033-6036(2012) 2.Kart, A., Yapar, K., Karapehlivan, M., et al.The possible protective effect of ?-carnitine on tilmicosin-induced cardiotoxicity in miceJ. Vet. Med. A Physiol. Pathol. Clin. Med.54(3)144-146(2007)
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